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Additional resources for Colorectal Cancer Biology - From Genes to Tumor

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Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients. 58-66, ISSN 1365-2125. ; Linardopoulous, S. & Balmain, A. (2003). 403-12, ISSN 1061-4036. ; Zheng, W. & Balmain, A. (2005). AuroraA/STK15 T+91A is a general low penetrance cancer susceptibility gene: a metaanalysis of multiple cancer types. 8, pp1368-73, ISSN 1460-2180. M. ; Campbell, H. G. (2005). Germline susceptibility to colorectal cancer due to base-excision repair gene defects.

247-57, ISSN 1533-4406. D. (2010). Homozygous BUB1B Mutation and Susceptibility to Gastrointestinal Neoplasia. 2628-37, ISSN 15334406. H. & van’t Veer, L. (2010). TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and Germline Genetics in Colorectal Cancer Susceptibility and Prognosis 33 relative frequency of cancers in different familial phenotypes. Journal of Medical Genetics, Vol. 421-428, ISSN 1468-6244. J. & Demant, P. (2002). Ptprj is a candidate for the mosue colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.

Interactions between dietary factors and genotypes have also been observed for CRC. , 2009). Much work remains to be done to fully assess geneenvironment interactions for CRC. 6 Modifier genes for penetrance in high-risk syndromes The risk of cancer does not reach 100% even for individuals with mutations leading to highpenetrance CRC syndromes like LS. Thus, it has been proposed that even in the context of a mutation, environmental factors and low-penetrance variants may impact cancer risk. To this end, modifier genes, alleles that modify the risk of a mutation, have been sought.

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