By Robert A. Vukovich Ph.D., James R. Knill M.D. (auth.), David B. Case, Edmund H. Sonnenblick, John H. Laragh (eds.)
This monograph was once constructed from a suite of papers that have been origi nally provided at a symposium entitled "Pathogenesis of high blood pressure" held on the Henry Chauncy convention middle, Princeton. New Jersey. those manuscripts have been hence revised, up to date, and reorganized in a fashion appropriate for this book. The symposium was once deliberate to stimu past due curiosity between investigators and clinicians alike within the power for a brand new classification of substances referred to as changing enzyme inhibitors in medical medication. The assembly was once backed through the Squibb Institute for clinical examine, whose pioneering biochemical and pharmaceutical study had resulted in the advance of the 1st orally energetic changing enzyme inhibitor. it's was hoping that this monograph will cohesively pull jointly the thesis that the identity, quantification, and containment of the renin consider high blood pressure could be a robust diagnostic and healing technique in scientific drugs. moreover, the series of experiences provided during this manuscript will serve to illustrate how simple biochemical and physio logical study produces basic and important info on which next significant advances in medical pharmacology and medication will be based.
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Additional resources for Captopril and Hypertension
The arterial pressure under the bars represents the average value for that interval. (From Muirhead et al. 21) 2KGH, partial nephrectomy-salt, and angiotensin-salt types. The Tr TCric exerted a powerful antihypertensive action, on occasions within 6-12 hr (Figures 4 and 5). In time, these transplants consisted mostly of RIC and capillaries and had the appearance of an endocrine organ. The antihypertensive action of cultured RIC occurs in the absence of natriuresis-diuresis. This experiment has been confirmed in at least one other laboratory (D.
Prostaglandins 3:581-594, 1973. Zusman RM, Keiser HR: Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. J C/in Invest 60:215-223, 1977. Dunn MJ, Staley RS, Harrison M: Characterization of prostaglandin production in tissue culture ofrat renal medullary cells. Prostaglandins 12:37-49, 1976. Muirhead, EE, Germain, GS, Pitcock, JA, Brooks, B, Leach, BE: The renal meduIJa and the hypertensive state, in Fregly J, Fregly MS (eds): Oral Contraceptives and High Blood Pressure.
5. 6. 7. 8. 9. 10. II. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 37 experimental procedures on the blood pressure of the dog. Am J Physiol. 157:21-30, 1949. FJoyer MA: Further studies on the mechanism of experimental hypertension in the rat. Clin Sci 14:163-181, 1955. Kolff WJ, Page IH, Corcoran AC: Pathogenesis of renoprival cardiovascular disease in dogs. Am J Physiol 178:237-245, 1954. Muirhead EE, Jones F, Stirman JA: Hypertensive cardiovascular disease of dog, relation of sodium and dietary protein to ureterocaval anastomosis and ureteral ligation.