Cancer metastatis, molecular and cellular mechanisms and - download pdf or read online

By Wen G Jiang; R E Mansel

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Sample text

Activity to digest the underlying basement membrane and hence gain access to the mesenchymal tissue as part of the invasive phenotype distinguishing benign from malignant cancers. The matrix metalloproteinase family has many members and is subdivided into four families. Two members of this family have marked activity against gelatin and hence are termed the gelatinase members of the family. One member of 72 kDa has variously been called MMP-2 or gelatinase A or the 72 kDa Type IV collagenase and the other, a 92 kDa protein is MMP-9 or gelatinase B or the 92 kDa Type IV collagenase.

Miyake H, Hara I, Yamanaka K, Gohji K, Arakawa S, Kamidono S. Elevation of serum levels of urokinase-type plasminogen activator and its receptor is associated with disease progression and prognosis in patients with prostate cancer. Prostate 1999; 39: 123–129. Montesano R, Pepper MS, Mohle-Steinlein U, Risau W, Wagner EF, Orci L. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 1990; 62: 435–445. Mustjoki S, Alitalo R, Stephens RW, Vaheri A.

J. ), Proteases and Their Inhibitors in Cancer Metastasis, 39–52. © 2002 Kluwer Academic Publishers. Printed in the Netherlands. activity to digest the underlying basement membrane and hence gain access to the mesenchymal tissue as part of the invasive phenotype distinguishing benign from malignant cancers. The matrix metalloproteinase family has many members and is subdivided into four families. Two members of this family have marked activity against gelatin and hence are termed the gelatinase members of the family.

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