Read e-book online Cancer Drug Discovery: Science and History PDF

By Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim

The reader will find a complete and multifaceted assessment of the historical past of the advance of anticancer medicines deeply encouraged by means of the cellphone idea of melanoma and destiny instructions for the improvement of recent anticancer medications. First, this publication records the clinical development in organic technological know-how during the last 70 years and the effect this development had in melanoma examine. Summaries and charts of vital discoveries whole this evaluate. in addition, this e-book outlines the method of anticancer drug improvement with a spotlight at the attribute drug teams of every period, regarding developments of chemistry and organic sciences. This publication additionally offers short mechanism of motion of substances, illustrated via finished timelines and conceptual cartoons. This e-book eventually sums up the restrictions of the present anticancer drug improvement and seeks new instructions for anticancer drug discovery, contemplating below the systemic view of cancer.

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In 1896, V. Despeignes became the first to use radiation to treat gastric cancer. In 1902, E. H. Grubbe widely started using radiotherapy in cancer patients, and radiotherapy became increasingly popular [5]. In 1889, the Curiés discovered radium, which emitted stronger radiation, and brought high-dose radiotherapy to the forefront. Whereas high-dose radiotherapy was effective against local cancers, it triggered the development of secondary cancers due to radiation-induced mutation of normal cells.

Schleiden T. Schwann Discovery of anesthesia W. Morton 1838 "Seed & Soil" hypothesis - organpreference patterns of tumor metastasis S. S. C. Virchow Blastema theory of cancer—Neoplasm R. C. A. H. 5 Advancement of science, history of cancer, and cancer drug development 44 Advancement of the Science and History of Cancer and Anticancer Drugs 1940 1938 [1931–1950] 1928 1927 1915 1909 1909 Introduction of the term “molecular biology” W. Weaver Purification of actinomycin D S. Waksman Discovery of penicillin, an antibiotic A.

As the various oncogenes and tumor suppressor genes discovered in previous studies acted as the core regulatory factors of cell division, anticancer drugs that targeted such factors began development. One example is trastuzumab (Herceptin), developed in 1990, an antibody that targeted the oncogene Her-2 of some breast cancers. Imatinib (Gleevec), which targeted the oncogene Bcr-Abl kinase of chronic myeloid leukemia (CML), was developed in 1996, and introduced the moleculetargeted therapy that inhibited only the activated oncogenes [69].

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