By Georges Mathé MD (auth.)
I wish to thank all my co-workers who've collaborated with me, from 1963 formerly, in organic and scientific study within the box of melanoma energetic immunotherapy, of its immuno prevention and immunorestoration. they are going to frequently be quoted during this ebook. i'm really thankful to those that have helped me to jot down it by means of reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her prepared and effective co-operation within the preperation of the manuscript. i'm ultimately thankful to all authors of books or articles who approved me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. creation and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour pertaining to melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and mobilephone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen tiation 22 2. 2. three. T-Lymphocyte capabilities 25 2. 2. four. B-Lymphocyte capabilities 30 2. 2. five. Macrophage services 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms desirous about Tumour mobile Rejec tion 33 2. three. 1. 1. In vivo proof for Tumour Immunity 33 2. three. 1. 2.
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Extra info for Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration
Simplified scheme of physiological relationsship between different types of Lymphocytes and between these and macrophages (kindly prepared by D. 2. , 1970). , 1966; ORDER and WAKSMAN, 1969). The role of the thymus as a primary lymphoid organ appears to be mediated through a thymic hormone produced by the epithelial cells of the gland (TRAININ, 1974). In the mouse, the acquisition of surface alloantigens is part of the differentiation of bone marrow precursors to mature T-Iymphocytes and marks this process (SCHLESINGER, 1972).
1965; FEFER, 1969). The rarity of such positive results may be explained by the fact that, in this type of in vivo experiment, the life span of the antibody is short, and its concentration, as well as that of complement components in different parts of the tumour, may be limiting factors (WINN, 1972). Antibody bound specifically to target cells can induce cytotoxicity by activating non-immune effector cells, the K-cells. 5. V. , 1973a; BANSAL and SJOGREN, 1973) Cell-mediated cytotoxicity a Cytotoxic antibodies Blocking serum factors Progressive tumour growth + After complete tumour excision + + After tumour recurrence + ?
Continuation) Immunodeficiency Disease Number of Cases Ataxia-telangiectasia 42 Lymphosarcoma 18 Reticulosarcoma 7 Hodgkin's disease 3 Leukaemia 8 Ovarian dysgerminoma Mixed cystic glioma Cerebellar meduloblastoma Gastric adenocarcinoma 2 Basal cell carcinoma Wiskott-Aldrich syndrome Malignant reticuloendotheliosis 13 5 Lymphosarcoma, reticulosarcoma 5 Cerebellar astrocytoma Myelogenous leukaemia Leiomyosarcoma (multiple) Number (for 10QOOO inhabitants) 2500 2000 1500 1000 I ~' 10 30 / I I ,I I I 50 males - - - females I I ,I ,, I 500 I 70 90 Age Fig.