Allergy and Allergic Diseases: The New Mechanisms and by Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) PDF

By Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)

In allergic reaction and Allergic illnesses: the recent Mechanisms and Therapeutics, a exceptional overseas panel of researchers and clinicians evaluation the most recent findings at the mobile and molecular foundations of allergic ailments, fairly these of the airway, dermis, and bowel. the main issues taken care of span the diversity from epidemiology and the mechanisms of irritation, to signaling in pathogenesis and allergies. each one contributor treats the pathophysiology of hypersensitivity in numerous organ-based illnesses and syndromes, emphasizing very important new findings from mobile and molecular biology that light up those ailments, but additionally display vital leads for the improvement of novel medicines and healing suggestions.

hypersensitive reaction and Allergic ailments: the recent Mechanisms and Therapeutics highlights the interface among easy and scientific technological know-how in allergic illness. Its updated, clinically suitable technique constitutes the recent typical wisdom base in medical immunology and hypersensitive reaction, not just for experts, but additionally for internists, for scientists learning the mobile and molecular biology of irritation and immunity, and for researchers interested in drug discovery and therapeutics. Authoritative and well timed, allergic reaction and Allergic illnesses is obviously the contemporary quintessential new source for all physicians and investigators looking a deeper realizing of hypersensitive reaction in either its easy and medical elements.

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IL-15 is a more recently identified cytokine produced by multiple cell types. IL-15 shares most, if not all, of its activities with IL-2, including its capacity to induce B-cell growth and differentiation (172). However, assuming that IL-15 production in IL-2-deficient mice is normal, it is clear that IL-15 cannot substitute for the function of IL-2 in vivo, because these mice have multiple immunodeficiencies. 26 Part I I Epidemiology/IgE Although the effects of IL-2 on B-cells are well characterized, its role in the regulation of IgE synthesis is somewhat controversial, since both enhancing and inhibitory effects have been reported.

Wierenga EA, Snoek M, de Groot C, Chretien I, Bos JD, Jansen HM, Kapsenberg ML (1990) Evidence for compartmentalization of functional subsets of CD2+ T -lymphocytes in atopic patients. J Immunol 144:4651-4656. 48. Parronchi P, Macchia D, Piccinni MP, Biswas P, Simonelli C, Maggi E, Ricci M, Ansari AA, Romagnani S (1991) Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 88:4538-4542. 49. Yssel H, Johnson KE, Schneider PV, Wideman J, Terr A, Kastelein R, De Vries JE (1992) T-cell activation-inducing epitopes of the house dust mite allergen Der p I.

Clark EA, Ledbetter JA (1994) How Band T-cells talk to each other. Nature 367:425-428. 10. Aversa G, Punnonen J, Carballido JM, Cocks BG, De Vries JE (1994) CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B-cells. Semin Immunol 6:295-301. 11. Clark EA, Ledbetter JA (1986) Activation of human B-cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Nat! Acad Sci USA 83:4494-4498. 12. Jabara HH, Fu SM, Geha RS, Vercelli D (1990) CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B-cells.

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