Download e-book for iPad: Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

Offers helpful info at the intriguing and fast-moving box of melanoma research. Outstanding and unique experiences are provided on various issues.

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2005). In addition, due to the unique distribution of HBV genotypes in Asian and Western countries, the clinical significance and virologic characteristics of HBV genotype could only be reliably compared between genotypes B and C or genotypes A and D. , 2004, 2007). Similarly, genotype D has been shown to have a less favorable prognosis than genotype A (Liu and Kao, 2006). The clinical significance of genotypes E–H remains to be examined. Nevertheless, it should be emphasized that all HBV genotypes can lead to end-stage liver disease including cirrhosis and HCC.

2004). , 2002). , 2005). 5%. 2% in the other districts in Japan. In addition, subgenotype B1 was more frequently found in the group older than 65 years while subgenotype B2 was found in all age groups. These data suggest that HBV subgenotype B1 may run a more indolent course than subgenotype B2. HBV genotype C is divided into subgenotypes C1–C4. , 2005). When subgenotype C1 and C2 were compared, subgenotype C1 was associated with a higher tendency to develop basal CP (BCP) mutations (80% vs. 14), a higher prevalence of C at nucleotide 1858 (C-1858) (95% vs.

Genotype According to the heterogeneity of the virus sequence, at least eight HBV genotypes (A–H) are defined by divergence in the entire HBV genomic sequence > 8% (Schaefer, 2007). Epidemiologic studies have shown that each genotype has its distinct geographic and ethnic distribution (Kao, 2002; Kao and Chen, 2006). Genotypes A and D occur frequently in Africa, Europe, and India, while genotypes B and C are prevalent in Asia. Genotype E is restricted to West Africa, and F is found in Central and South America.

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