By Murat Emre (auth.), Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin (eds.)
Proceedings of the seventh foreign convention on Alzheimer’s sickness and Parkinson’s disorder (ADPD), held March 9-13, 2005 in Sorrento, Italy.
The material of the ADPD meetings is exclusive in that it offers not just with matters comparable separately to Alzheimer’s disorder and Parkinson’s illness, but in addition with the combination of those and different similar ailments. the main up to date thoughts and learn findings are illustrated during this quantity, overlaying subject matters corresponding to immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the background, epidemiology, scientific phenomenology, analysis, imaging, remedy ,and destiny views of Alzheimer’s and Parkinson’s Diseases.
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Extra info for Advances in Alzheimer’s and Parkinson’s Disease: Insights, Progress, and Perspectives
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Release of dopamine into the cytoplasm induces oxidative stress to nigral neurons. Both oxidative stress and mitochondrial impairment enhance alphasynuclein aggregation. In addition, mitochondrial impairment results in reduced ATP synthesis: As 26S proteasome is an ATP-dependent proteindegrading enzyme, mitochondrial impairment reduces its catalytic activity. Thus, vicious cycles are formed in nigral neurons, leading them to progress slowly toward neuronal death. Furthermore, aggregated insoluble alphasynuclein proteins are likely to impair transport of vital substances in nigral neurons.
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